Terminally differentiating stratified squamous epithelial cells assemble a specialized protective barrier structure on their periphery termed the cornified cell envelope (CE). It is composed of numerous structural proteins that become cross‐linked by several transglutaminase enzymes into an insoluble macromolecular assembly. Several proteins are involved in the initial stages of CE assembly, but only certain proteins from a choice of more than 20 different proteins are used in the final stages of CE reinforcement, apparently to meet tissue‐specific requirements. In addition, a (...) variable selection of proteins may be upregulated in response to genetic defects of one of the CE proteins or tissue injury, in an effort to maintain an effective barrier. Additionally, in the epidermis and hair fiber cuticle, a layer of lipids is covalently attached to the proteins, which provides essential water barrier properties. Here we describe our current understanding of CE structure, a possible mechanism of its assembly, and various disorders that cause a defective barrier. BioEssays 24:789–800, 2002. Published 2002 Wiley Periodicals, Inc. (shrink)

Recent years and months have evidenced an increase in deflationary phenomena. The present article defines the reasons for the problem, explains the irregularity of the inflation–deflation processes in the world and forecasts on this basis that the crisis-depressive phase of development in the global economy will continue for a relatively long time. Based on an analysis of available resources and the theory of long cycles, we believe that in the next 5–10 years, the global economy will continue being in the (...) crisis-depression phase with rather sluggish and weak rises. The article also offers some forecasts for the forthcoming sixth Kondratieff wave, identifies its possible technological basis, and discusses possible consequences of the forthcoming technological transformations. (shrink)

O presente trabalho tem o objetivo de conectar a teoria criada por Pierre Bourdieu sobre a violência simbólica e o texto de Audre Lorde, The use of anger: women responding to racism do seu livro Sister Outsider; demonstrando a importância do debate sobre a relação entre dominante e dominado a partir do viés racial, tema abordado por ambos autores em seus textos. Com este fito, pretendemos diferenciar os resultados objetivos do ódio, raiva e culpa, bem como o modo que as (...) agressões invisíveis repercutem na vida do oprimido. Tendo como foco o racismo na vida da “mulher de cor” que ainda nos dias de hoje, em uma pirâmide social, se encontram em desvantagem quanto aos demais indivíduos. Faz parte dos objetivos também trazer à tona a reação do oprimido como consequência natural dos séculos de silenciamento, privação e desumanização, analisando os mecanismos institucionais para pacificação social. (shrink)

The Transamazon (Br-230) Highway in the state of Pará has had its image frozen for decades: themuddy road, the cars stopped or tractors tearing down a forest, empty of people, opening the amazonianspace to a project of an authoritarian modernization. Reproduced by and reproductive of the teachingsof geography – including for children and teenagers who live on the edge of the road, in settlements andcommunities on the sideroads (vicinais) – in textbooks and discourses that frame regional scale (astotalizing and explanatory) (...) instead of scales emplaced in situ. The result of such dinamics is not restricted to a gap between what one experiences as a phenomenon and what one learns as a concept,it goes towards the reproducibility of an “unexistance of the creative potential” of the people living onthe sideroads, places of the construction of a geography, as well as mapping, that, from there, push usto rethink the unwavering foundations of such frosen images , of the generalistic maps and theirstandardizing projections, scales and simbology. To do so, we have, along with students and teachersof 2 schools on the sideroads of the municipality of Pacajá (PA), in the period of the beggining of 2016to 2019, done several geocartographic exercises: mind maps developped with students about the past,present and the future of the vicinal (sideroad). That is, an attempt to provoque the body into the mapand the map into the body in a context of a limit situation of existance, given the precarious schoolconditions as well as the diferent challenges lived by students and teachers. Such corporal engagementas an attempt to think the sideroads as a location in construction and, from there, a situated opening tothe world, is what gives meaning to geocartography. It is possible to conclude that: a) facing thesedimentary representations paralysing and overview of the Transamazon in the state of Pará , thephenomenological exercise of reactivation of geocartogrphying provoques the emergence of asubjective significance that does not separate the emotional and symbolic perspectives on creatingmaps; b) the corporal engagement and the situated perspective of students and teachers, not only hasthe value of a totalyzing exemple, but that of an opening to what is new as they bring up a simbologythat reveals the need to build a dialogical bridge between what is lived on the sideroads and the worldthat classifies it as “unexisting”. (shrink)

The paper is aimed at providing general outlines of the more than two-century history of the theory of moral sanctions. It rests on a thesis about unity of all disciplines studying morality. The aim of the paper has been achieved trough an analysis of how some basic concepts were borrowed and basic ideas were transformed. The first tradition links moral sanctions with public condemnation. Some of its adherents simply identified public condemnation with moral sanction. This opinion prevailed until the middle (...) of the XXth century. Later it was suggested that a sanction becomes genuinely moral only when a transgressor herself is sensitive to condemnation because she recognizes that she deserves it and feels shame, guilt or remorse. It means that an external side of the sanction has to be complemented by an internal one. The first tradition presupposes a deep and thorough analysis of an external side of the moral sanction, i.e. various forms of sanctioning behavior (avoidance, censure, denunciation, reproach, scolding etc.) The second tradition was initiated by J.S. Mill and H. Sidgwick, it includes among moral sanctions the very negative emotions of self-appraisal. For adherents of this tradition, model and most important moral sanctions are internal: guilt and remorse. Characteristics of internal (autonomous) and external (heteronomous) sanctions were established in the XXth century anthropology. Later this distinction became current in the contemporary ethics. (shrink)

I proceed from the hypothesis that the difficulties in Kant’s presentation of his plan and, accordingly, the implicit reason for the critical attitude to this plan on the part of many contemporary philosophers stem from the fact that he had no theoretical link at his disposal which would offer a more solid scientific grounding for his entire system. I believe that Darwinism is such a link which bolsters the central but ungrounded thesis of the Critique of Pure Reason on the (...) existence of a priori synthetic judgments. The synthesis of Darwinism and critical philosophy dictates, however, a substantial restructuring of the latter since some of its key elements prove to be weak in the light of modern studies and need to be revised or even reversed. The first reversal explored in this article determines the origin of the categories which are now revealed not “from the top down” where Kant sought them, i. e. not in logical functions in accordance with metaphysical deduction and not in self-consciousness as transcendental deduction claims, but “from the bottom up” if one considers things in the evolutionary dimension, i. e. in the instincts. The second reversal shifts the freedom of will which Kant placed in the same ontological basket with things in themselves at “the top,” to another level of the pyramid of ontologies, by changing dualism to pluralism because dualism is too narrow to accommodate all the autonomous components of critical philosophy. Thus spirit and freedom find a new place separate from the sphere of physical nature; the category of adaptation explains how different ontologies can coexist; while the problem of two interpretations of transcendental idealism finds a solution through their reconciliation. (shrink)

The starting point of my study is Kant’s remark to the effect that Garve in his treatise on the connection between morality and politics presents arguments in defence of unjust principles. Recognition of these principles is, according to Kant, an inadvisable concession to those who are inclined to abuse it. I interpret this judgement by making a detailed comparison of the texts of the two treatises. I demonstrate that Garve’s work is an eclectic attempt to combine in one concept the (...) lessons of historical experience with the ideas drawn from British empiricism and German rationalism. These ideas were criticised by Kant in his “critical” period. There is a consensus among researchers that Garve condoned the expansionist policy of Frederick II of Prussia, totally denied that legality in international relations was possible and in general deserved the reputation of an conservative. From that point of view the key values for Garve were the security and well-being of the state. I offer an alternative interpretation of Garve’s position because I believe that the value of political stability plays an important role in it. Such an interpretation makes it possible to treat Garve’s narrative as it was assessed by Kant, i.e. as a concession to the common principles of political practice as a result of a failure to find the guiding theory. My study has established that the role of Garve’s work in the writing of Kant’s treatise Toward Perpetual Peace was more significant than Kant’s own words suggest. Besides, I show that it was under Garve’s influence that Kant turned to the problem of excessive complexity of the principles involved in the search for concrete political decisions. Garve obviously laments this complexity and yet makes these principles still more complex. Kant offers a simpler solution of the problem on the basis of his theory of morals and right. (shrink)

Este artigo busca expor as críticas de Bernardo de Claraval às superfluidades humanas no texto da Apologia , especialmente aquelas referentes à arte arquitetural. Em segundo lugar, procura analisar as implicações estéticas do ascetismo cisterciense e bernardiano. As críticas de Bernardo exercem uma influência decisiva na ornamentação e fazem nascer uma nova arquitetura.

: I reformulate and elaborate on important claims relevantly put for debate by the commentators, i.e., counterfactuals are a form of observable experience rather than a plurality of ….

Este artigo busca expor as críticas de Bernardo de Claraval às superfluidades humanas no texto da Apologia, especialmente aquelas referentes à arte arquitetural. Em segundo lugar, procura analisar as implicações estéticas do ascetismo cisterciense e bernardiano. As críticas de Bernardo exercem uma influência decisiva na ornamentação e fazem nascer uma nova arquitetura. This paper is to expose the criticism of human superfluities at Bernard of Clairvaux in the text of the Apology, especially those related to architectural art. Secondly, analyzes the (...) aesthetic implications of cistercian and bernardian asceticism. Criticism of Bernard exercise a decisive influence on ornamentation and give birth to a new architecture. (shrink)

Article is dedicated to the description and analysis of metaphilosophical and scientific contexts of the McTaggart paper ‘The Unreality of Time’ (1908) and drawing connections to the ‘analytical’ style of his pupils – B. Russell and G.E. Moore. Main line of argument against the reality of time is presented and analyzed. By the positive relation of McTaggart to the work on ethics by G.E. Moore and negative – to philosophical implications of the special theory of relativity author shows the movement (...) for the autonomy of philosophy or ‘antipsychologism’. Question of a different understanding of the term ‘reality’ in Moore and McTaggart is posed and resolved. (shrink)

Objective: To explore the strategies that can help individuals mourning a family member’s death from Covid-19 to cope with the loss. Method: We carried out a narrative review on the PubCovid-19 platform using the descriptors “death,” “mourning,” “Covid-19,” and “coping strategies.” Ten articles were included. Results: The strategies found are phone calls, audio recording, letters, and photos, classified as immediate and long-term. These strategies are focused on mental health, which can be adversely affected by depression and psychological disorders. Conclusions: Creating (...) counseling programs for the relatives of those who died from Covid-19 is urgent. They must offer comprehensive, humanized, and continuous mental health care. (shrink)

For a long time, leading European thinkers have denied systematic, theoretical and rational nature of Chinese traditional thinking, unpretentiously reading it as banal moralizing, not supported by any proper philosophical discourse. However, the habitual socioethical label conceals a much deeper problematic of strategic thinking. At its center, there is the question of choosing all sorts of strategies: from everyday life to special technical ones, from personal existential choice to fateful state decisions. The concept of a winning strategy is emblematized by (...) the dramatic plot of a deadly risk but under certain conditions with guaranteed happy end. The strategy of harmony, which is miraculous in its effectiveness, is proposed as a exemplary strategy. It allows you to “step on the tiger’s tail” with impunity. From the point of view of strategic thinking, the criterion of cognitive value of reasoning is its effectiveness, and the most effective is unmistakable prediction, i.e. the ability to predict the outcome of future developments with the help of reasoning. In the ideal case, prognostic reasoning becomes not just plausible but 100% reliable that is an apodictic true inference. Therefore, the highest cognitive status in the Chinese intellectual tradition is endowed with guaranteed error-free prognostic reasoning. This type of reasoning, where the reliability of foresight is guaranteed by the implementation of a certain winning strategy, can be called the prognostic form of deduction. As a result, the dynamism of Chinese logic, which relies on a deliberate staging of the future, is strikingly different from the static nature of the classical image of logic, where logic is no more than a static guardian of correctness of reasoning. On the contrary, the Chinese concept of logic focuses on deriving consequences from strategic considerations regarding the future, actively and purposefully shaped by the subject who at the same time constructing both himself and the world around him. (shrink)

This article considers the history of Soviet Spinoza studies after World War II. V.V. Sokolov, editor of the last Soviet publication of Spinoza’s works, regards him as a metaphysician, at times rising to dialectics, and a pantheist rising to materialism. E.V. Ilyenkov, Ya. A. Milner and B.G. Kuznetsov offer a radically different interpretation of Spinoza, as our advanced contemporary. The article provides a critical analysis of the concept of man as a “thinking body,” which Ilyenkov mistakenly ascribes to Spinoza and (...) then corrects on behalf of Marx. Kuznetsov, in his own words, performs a “neo-Spinozist analysis of science.” He is looking for equivalents of Spinoza’s concepts in modern physics, starting with the “physically meaningful” concept of being. Milner wrote a new Ethics, based on the concept of “free necessity” as a social duty consciously performed by the individual. (shrink)

We establish that for every computably enumerable (c.e.) Turing degree b the upper cone of c.e. Turing degrees determined by b is the degree spectrum of the successor relation of some computable linear ordering. This follows from our main result, that for a large class of linear orderings the degree spectrum of the successor relation is closed upward in the c.e. Turing degrees.

A sociedade brasileira no que diz respeito a sua estrutura de relações sociais como conhecemos, tem início no Brasil colônia a qual a instituição de maior força era a escravagista. Nesse sentido, as formações e interações de classes da sociedade brasileira foram arregimentadas pelo racismo, sendo ele escancarado no passado, com leis e naturalização das práticas de disciminação racial, e mantendo grande influência atualmente com a utilização de “máscaras” que encontram para legitimar sua atuação na sociedade contemporânea. Nesse contexto, nos (...) últimos anos tem-se observado a atuação irregular de ações policiais no país, principalmente nas comunidades periféricas, sendo utilizada a brutalidade e a violência física e moral dos sujeitos, violando direitos humanos e fundamentais, e colocando em perigo a vida de crianças e adolescentes que residem nesses ambientes, sobretudo, as negras, reconhecendo assim a existência do racismo estrutural. Considerando que o país é democrático, e reconhecendo que os atores sociais possuem a capacidade de influenciar nas mudanças e construções de políticas capazes de discutir os fundamentos da vida pública e social, esta proposta de pesquisa tem por objetivo refletir como a brutalidade policial afeta a confiança de crianças negras no Estado democrático por meio de instituições de segurança e proteção. Trata-se de uma pesquisa de revisão bibliográfica, qualitativa e descritiva. (shrink)

This review covers the content of reports and discussions at the 12th Kant Readings Conference held in April 2019 and organised by the research unit of the Academia Kantiana of the Immanuel Kant Baltic Federal University, Kaliningrad. Traditionally, Kant Readings have been thematically universal, embracing all the areas of Kant’s legacy. This time the conference focused on practical philosophy, i.e. the historical grounds and modern significance of Kant’s ethical thought as compared to other philosophical projects of the Enlightenment era. Due (...) attention was paid to the reception of the ethics of Kant and the Enlightenment by philosophers in Russia and the West. Breakout groups discussed aspects of interconnection between the Enlightenment ethics and esthetics as well as interdisciplinary problems at the interface of philosophy of politics and philosophy of education, including ways to counter various forms of intellectual enslavement. The possibilities of applying Kant’s ethical principles were discussed in close connection with the interpretation of the latest trends in the development of science and technology. It was noted that the intellectual and social communication environment of today has much in common with that of the Enlightenment era, which makes the philosophical strategy proposed during that era amenable to adaptation and development. (shrink)

The present Yearbook (which is the fourth in the series) is subtitled Trends & Cycles. Already ancient historians (see, e.g., the second Chapter of Book VI of Polybius' Histories) described rather well the cyclical component of historical dynamics, whereas new interesting analyses of such dynamics also appeared in the Medieval and Early Modern periods (see, e.g., Ibn Khaldūn 1958 [1377], or Machiavelli 1996 [1531] 1). This is not surprising as the cyclical dynamics was dominant in the agrarian social systems. With (...) modernization, the trend dynamics became much more pronounced and these are trends to which the students of modern societies pay more attention. Note that the term trend – as regards its contents and application – is tightly connected with a formal mathematical analysis. Trends may be described by various equations – linear, exponential, power-law, etc. On the other hand, the cliodynamic research has demonstrated that the cyclical historical dynamics can be also modeled mathematically in a rather effective way (see, e.g., Usher 1989; Chu and Lee 1994; Turchin 2003, 2005a, 2005b; Turchin and Korotayev 2006; Turchin and Nefedov 2009; Nefedov 2004; Korotayev and Komarova 2004; Korotayev, Malkov, and Khaltourina 2006; Korotayev and Khaltourina 2006; Korotayev 2007; Grinin 2007), whereas the trend and cycle components of historical dynamics turn out to be of equal importance. (shrink)

ABSTRACT Discourse Diversity Database (3D) is a corpus designed for clinical linguistics research. It consists of oral speech samples of three different genres: picture-elicited narratives, personal stories, and picture-based instructions. The sub-sections of 3D include recordings by Russian speakers from three independent groups: people with brain tumors before and after tumor removal, people with schizophrenia, and neurologically healthy individuals. This article is devoted to the description of the data collection, the annotation scheme, and the specific characteristics of each sub-section of (...) the corpus. (shrink)

RESUMO O Discourse Diversity Database (3D) é um corpus desenvolvido para a pesquisa em linguística clínica. Ele consiste de amostras de fala oral de três gêneros diferentes: narrativas induzidas por imagens, histórias pessoais e instruções baseadas em imagens. As subdivisões do 3D incluem gravações de falantes de russo de três grupos independentes: pessoas com tumores cerebrais antes e depois da remoção do tumor, pessoas com esquizofrenia e indivíduos neurologicamente saudáveis. O presente artigo é dedicado à descrição do procedimento de coleta (...) de dados, do esquema de anotação e das características específicas de cada subdivisão do corpus. (shrink)

Henri JM Claessen Was the State Inevitable? ● Leonid E. Grinin The Early State and Its Analogues: A Comparative Analysis ...

In this chapter, we analyze the relationship between Kondratieff waves and major technological revolutions on the basis of the theory of production principles and production revolutions, and offer some forecasts about the features of the Sixth Kondratieff Wave/the Fourth Industrial Revolution. We show that the technological breakthrough of the Sixth Kondratieff Wave may be interpreted as both the Fourth Industrial Revolution and as the final phase of the Cybernetic Revolution. We assume that the sixth K-wave in the 2030s and 2040s (...) will merge with the final phase of the Cybernetic Revolution (which we call a phase of selfregulating systems). This period will be characterized by the breakthrough in medical technologies which will be capable of combining a number of other technologies into a single system of new and innovative technologies (we denote this system as a system of MANBRIC-technologies—i.e. medical, additive, nano-, bio-, robo-, info-, and cogno-technologies). (shrink)

This interview with Professor Dr Jürgen Stolzenberg, board member of the Kant-Gesellschaft and co-editor of the Kant-Lexikon (2015), explores a wide range of topics — from Leibniz and Wolff to Heidegger and Husserl. The leading idea of Stolzenberg’s philosophical research is the justification of the principle of modern subjectivity in Kant’s philosophy and its transformations until our days. He discusses the meaning and development of the concept of self-consciousness and the understanding of subjectivity in Kant’s ethics as well as in (...) Fichte’s philosophy. Stolzenberg shows the significance of Heidegger’s philosophical relations with Kant, Fichte, and the Neo-Kantians. He outlines the reasons which explain the different structures of the philosophical theories after Kant in comparison with the structure of Kant’s philosophy itself. Answering the question of Kant’s role in affirming the value of human dignity, he emphasises the non-empirical essence of this concept as it is presented in Kant’s ethics and as it should be defended against recent critics. According to Stolzenberg, the principle of modern subjectivity proves to be fruitful in understanding the development of the history of modern music, too. (shrink)

The construct of moral intensity, proposed by Jones (1991), was used to predict the extent to which individuals were able to recognize moral issues. We tested for the effects of the six dimensions of moral intensity: social consensus, proximity, concentration of effect, probability of effect, temporal immediacy and magnitude of consequences. A scenario-based study, conducted among business individuals in Singapore, revealed that social consensus and magnitude of consequences influenced the recognition of moral issues. The study provided evidence for the effects (...) of temporal immediacy. There was marginal support for the impact of proximity and probability of effect but no evidence that concentration of effect influenced recognition of moral issues. The paper concludes with a discussion of the implications of these results for researchers and organisational practitioners. (shrink)

A significant discrepancy in Wittgenstein's studies is whether Philosophical Investigations contains any trace of positive philosophy, notwithstanding the author's apparent anti-theoretic position. This study argues that the so-called ‘Chapter on philosophy’ in the Investigations §§89–133 contains negative and positive vocabulary and the use of various voices through which Wittgenstein employs his primary method of language-games, thus providing a surveyable understanding of several philosophical concepts, such as knowledge and time. His positive philosophy aims to reorient our attention from understanding the theories (...) on these concepts to understanding the concepts themselves, regardless of any theorisation. (shrink)

In this article, I present a sociological approach to the problem of meaningful work that dwells on its broad social and cultural sources, as opposed to the focus on subjective and organizational factors currently prevailing in the field. Specifically, I consider two sociological perspectives, those of community and autonomy, as important conceptual tools for understanding the ambivalent character of modern culture in providing individuals with a sense of meaningfulness of their activities. I also review some of the existing research on (...) meaningful work and interpret it through this conceptual distinction, both to show the latter’s relevance for the field and to identify the gaps it might help fill. As a result, based on the sociological perspectives, I propose a general conceptual model and discuss five directions to further advance the theoretical comprehension of meaningful work, and I suggest some implications of these perspectives for normative business ethics. (shrink)

To ensure that listeners pay attention and do not habituate, emotionally intense vocalizations may be under evolutionary pressure to exploit processing biases in the auditory system by maximising t...

Multidrug resistance (MDR) is developed in a population of somatic mammalian cells in vivo or in vitro when they are selected for resistance to each of a large group of drugs (colchicine, adriamycin, actinomycin D, etc.). It is produced by the amplification of some unknown gene(s) whose product(s) evidently change(s) the plasma membrane permeability of a cell to a selective agent and to other unrelated compounds. A large specific genomic region (150–250 kbp) undergoes amplification in MDR cells selected for the (...) resistance to different drugs. Amplified DNA is located in homogeneously staining regions of chromosomes, double minute chromosomes and small chromatin bodies – episome‐like structures that replicate out of the S‐phase of a cell cycle. The selection of MDR cell variants is accompanied by regular karyotypic evolution specific for this type of drug resistance. (shrink)

The paper aims to formulate theoretical and methodological foundations as well as basic research questions for studying intervention of artificial intelligence in everyday life of medical and life sciences in the 21 century. It is an invitation for professional philosophical, theoretical and methodological discussion about the necessity and reality of artificial intelligence in contemporary medical/life sciences and medicine. The authors commence with a proposition of their definitions of ‘artificial intelligence’ (AI) and ‘artificial sociality’ (AS). The next section of the paper (...) deals with a review of basic trends in medical/life sciences and medicine. In what follows the authors debate two problems related to incorporation of AI in reality of current medicine. The first is the potential revision of the principles developed in western medicine; the second is the alteration of the contents and forms of medical education. The authors theorize the dynamic interplay between structural expansion and cultural contraction of medicine and life sciences in current practices of higher education and explore how this introduces an essential tension between the necessity and reality for medical professionals to work with AI. The paper shows that attending to institutional dynamics serves as a critical and timely extension of disciplinary/cross/anti-disciplinary critiques of science and medicine, not only since the current inclusion agenda of the AI in medicine may do little to address the real concerns of a medical profession in the XXI century but also because it may inadvertently undermine the institutional recognition and epistemic acceptance of new anti-disciplinary vista for studying AI per se. In conclusion the authors underline basic outcomes of the discussion and propose further routes for inquiry and research. (shrink)

While regarding twentieth century French philosophy as a protracted conceptual war, Badiou has largely avoided an encounter with Foucault on the philosophical battlefield. According to Badiou, Foucault constructs a history of systems of thought starting from something other than philosophy (linguistic anthropology, postmodern sophism, democratic materialism) and, in so doing, exits the philosophical battleground. The present essay explores the prospect of rapprochement between these two thinkers, drawing attention to their shared concern with the theme of true life. For Foucault and (...) Badiou, the life in truth and for truth compels the subject to invent a new way of being at the site of exception to what there is. Although Badiou remains ambivalent about the Foucauldian notion of the philosophical subject, he ultimately endorses Foucault’s conception of the philosophical life, which calls for courage insofar as it summons the human animal to think differently and become other than what one is. (shrink)

Стаття присвячена аналізу складного і суперечливого процесу демократизації арабського суспільства, який відбувається вже багато років. Сучасні глобалізаційні процеси торкнулися і арабського світу, де спостерігається зіткнення цивілізаційних парадигм. Разом з тим наголошується, що існуючі соціальні конфлікти та елементи суспільно-політичної нестабільності, які торкнулися ряду арабських країн, частково є результатом західного впливу і нав'язування інститутів, не властивих арабської соціокультурної традиції. З іншого боку, всі ці феномени цілком можливо розглядати як етап своєрідної демократизації арабського соціуму, який потрібен як важлива складова відповідного процесу.

The paper presents the reflection on philosophical foundations of contemporary physical concepts of global history and global structure of Universe. It shows that Democritus's dualism of "matter and void" is changed now in dualism of "matter and energy" in the frame of the strings theory, where anything what looks like "a void" is absent. At the same time the Poincare-Perelman's theorem calls to rethink Democritus's philosophy in the light of "space and hole" discourse and call it to come back. On (...) the level of philosophy doctrines for contemporary fundamental physics it in necessary to combine dialectically the concept of "matter and void/hole" and the concept "matter and energy" (or "matter and singular conditions"). It is possible to do on the way of rethinking of H. Bergson's ideas presented in his book "Matter and memory". The conclusion is that fundamental dualism consists the relation "visible matter - invisible historical memory" inside of Universe. (shrink)